报告题目：Genius, Luck, or Negative Controls: Salmonella Tell the Story
报告人：Dr. Daoguo Zhou, Purdue University, USA
报告时间：2011年4月8日（周五）下午2:00- 3:30
报告地点：生命科学学院245报告厅
联系人：haichung@zju.edu.cn 
 Pathogenic Salmonella strains cause food poisoning, gastrointestinal inflammation, typhoid fever, and septicemia in humans. The bacteria achieve this by making a panel of specialized proteins that allows it to invade non-phagocytic intestinal epithelial cells, the first step in the disease process. Previous research has established that upon contact with the intestinal epithelial cells, Salmonella injects a set of proteins into the host cells through the bacterially encoded type III protein secretion system. These proteins subvert host cell signal transduction pathways to induce profuse actin cytoskeletal rearrangements and membrane ruffling, leading to the uptake of the bacterium. This uptake process is a highly regulated event and requires the coordinated action of the injected bacterial proteins as well as host proteins. My laboratory is interested in identifying and characterizing bacterial and host cellular proteins that are involved in Salmonella -induced actin cytoskeletal rearrangements, especially cellular proteins whose activities are modulated by Salmonella proteins. Studying the interaction between bacteria and their hosts has emerged as one of the most exciting areas of cellular microbiology. It will not only broaden our understanding of bacterial pathogenesis, but also will provide unexpected insights into basic host cellular functions, such as the cytoskeletal rearrangements and signal transduction pathways controlling cell movement
Dr. Zhou, associate professor at Purdue University (West Lafayette, IN), is seeking high-quality students for Ph.D program and graduating Ph.D for Postdoc. If interested, please stop by room 235 on 24.